Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27490020 | 0.80 | MAPK1 (0.61) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL8942192 | 0.80 | TDP1 (0.58) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL28043395 | 0.79 | CES1 (0.66) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL11068120 | 0.79 | TSHR (0.59) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL7798061 | 0.78 | PLOD2 (0.44) | CES1CA1CA2ALDH1A1SLC6A2 | |
| SCHEMBL4875245 | 0.78 | MAPK1 (0.62) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL3124518 | 0.76 | MAPK1 (0.60) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL19762742 | 0.76 | MAPK1 (0.51) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL1459733 | 0.75 | MAPK1 (0.58) | MAPK1CES1CA1CA2TDP1 | |
| SCHEMBL29084329 | 0.75 | MAPK1 (0.58) | MAPK1CES1CA1CA2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2001-12-27 | — | — | US | disclosed |
| US-6045773-A | Method of detecting cyclooxygenase-2 | G.D. SEARLE & CO. (US) | 2000-04-04 | — | — | US | disclosed |
| EP-0859642-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1998-08-26 | — | — | EP | disclosed |
| WO-1997014679-A2 | METHOD OF DETECTING CYCLOOXYGENASE-2 | G.D. SEARLE & CO. (US) | 1997-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010055565-A1 | Method of detecting cyclooxygenase-2 | PTGS2, PTGES2, PTGER2 | MAPK1 4162/4885CES1 1407/4885CA1 906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.