Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | KMO | O15229 | 3/20 | 0.59 |
| ▸ | ALPI | P09923 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2860324 | 1.00 | TSHR (0.64) | TSHRKMOALPIPKMPTGS1 | |
| SCHEMBL2791083 | 1.00 | TSHR (0.64) | TSHRKMOALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL27416033 | 0.98 | TSHR (0.62) | TSHRKMOALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL27416030 | 0.98 | TSHR (0.62) | TSHRKMOALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL27417447 | 0.98 | TSHR (0.62) | TSHRKMOALPIPKMPTGS1 | |
| SCHEMBL11148099 | 0.86 | TSHR (0.53) | TSHRKMOALPIPKMPTGS1 | |
| SCHEMBL29151574 | 0.85 | KMT2A (0.55) | TSHRKMOALPIPKMPTGS1 | |
| SCHEMBL5281538 | 0.84 | KMO (0.60) | TSHRKMOALPISLC7A5KDM4E | |
| SCHEMBL9064982 | 0.84 | KMO (0.60) | TSHRKMOALPIPKMPTGS1 | |
| SCHEMBL10517046 | 0.83 | TSHR (0.63) | TSHRKDM4ETDP1HIF1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104592046-B | Optically active valine compound and production method thereof | 黄冈威尔曼生物科技有限责任公司 | 2017-02-22 | — | — | CN | claimed |
| EP-4617271-A1 | PROTEOLYTIC CHIMERAS FOR THE TREATMENT OF A CANCER RELATED TO CERT | Consejo Superior De Investigaciones Científicas - CSIC (ES) | 2025-09-17 | — | — | EP | disclosed |
| CN-104592046-B | Optically active valine compound and production method thereof | 黄冈威尔曼生物科技有限责任公司 | 2017-02-22 | — | — | CN | disclosed |
| US-20010008947-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES | VARASI MARIO (IT) | 2001-07-19 | — | — | US | disclosed |
| EP-0662948-B1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN SPA (IT) | 1998-10-07 | — | — | EP | disclosed |
| CN-1112786-A | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity | PHARMACIA SPA (IT) | 1995-11-29 | — | — | CN | disclosed |
| EP-0662948-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-07-19 | — | — | EP | disclosed |
| WO-1995003271-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010008947-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES | KYNU, KMO, ABAT | TSHR 4661/4885KMO 2/4885ALPI 2375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.