Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 13/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7799873 | 0.82 | SRD5A1 (0.67) | SRD5A1SRD5A2 | |
| SCHEMBL7799921 | 0.79 | SRD5A1 (1.00) | SRD5A1HTR1ASIGMAR1SRD5A2 | |
| SCHEMBL7789453 | 0.79 | SRD5A1 (1.00) | SRD5A1HTR1ASIGMAR1SRD5A2 | |
| SCHEMBL7789452 | 0.79 | SRD5A1 (1.00) | SRD5A1HTR1ASIGMAR1SRD5A2 | |
| SCHEMBL6249826 | 0.72 | SRD5A1 (0.44) | SRD5A1HTR1ASIGMAR1 | |
| SCHEMBL18779970 | 0.71 | SRD5A1 (0.57) | SRD5A1HTR1ASIGMAR1 | |
| SCHEMBL18779969 | 0.71 | SRD5A1 (0.57) | SRD5A1HTR1ASIGMAR1 | |
| SCHEMBL15887271 | 0.70 | HTR1A (0.66) | SRD5A1HTR1ASIGMAR1 | |
| SCHEMBL8900313 | 0.70 | HTR1A (0.67) | SRD5A1HTR1ASIGMAR1 | |
| SCHEMBL5603849 | 0.70 | AKR1C3 (0.45) | SRD5A1HTR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968219-A1 | NOVEL THERAPY FOR PROSTATE CARCINOMA | Pellficure Pharmaceuticals, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014158875-A1 | NOVEL THERAPY FOR PROSTATE CARCINOMA | PELLFICURE PHARMACEUTICALS INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| EP-0591583-B1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0532190-B1 | Benzo(f)quinolinones as 5-alpha-reductase inhibitors | LILLY CO ELI (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5541190-A | TREATING BENIGN PROSTATIC HYPERPLASIA, MALE PATTERN BALDNESS, PROSTATIC CANCER, ANDROGENIC ALOPECIA | ELI LILLY AND COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5495021-A | STEROID 5 ALPHA-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-27 | — | — | US | disclosed |
| US-5334767-A | Steroid 5a-reductase inhibitor | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |
| EP-0591583-A1 | Benzo (f) quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1994-04-13 | — | — | EP | disclosed |
| US-5239075-A | PROCESS FOR THE PREPARATION OF BENZO (F) QUINOLINONES | ELI LILLY AND COMPANY (US) | 1993-08-24 | — | — | US | disclosed |
| EP-0532190-A2 | Benzo f quinolinones as 5-alpha-reductase inhibitors | ELI LILLY AND COMPANY (US) | 1993-03-17 | — | — | EP | disclosed |