Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | GCK | P35557 | 15/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2646630 | 0.97 | KCNH2 (0.54) | KCNH2GCKAVPR1B | |
| SCHEMBL2645001 | 0.85 | KCNH2 (0.55) | KCNH2GCK | |
| SCHEMBL27482380 | 0.85 | KCNH2 (0.57) | KCNH2GCK | |
| SCHEMBL6562242 | 0.84 | KCNH2 (0.55) | KCNH2GCK | |
| SCHEMBL2646661 | 0.82 | GCK (0.68) | KCNH2GCK | |
| SCHEMBL2648514 | 0.81 | GCK (0.55) | KCNH2GCKAVPR1B | |
| SCHEMBL2645963 | 0.80 | KCNH2 (0.48) | KCNH2GCK | |
| SCHEMBL2645781 | 0.80 | KCNH2 (0.48) | KCNH2GCK | |
| SCHEMBL2647332 | 0.80 | ALDH1A1 (0.51) | KCNH2GCKALDH1A1TDP1 | |
| SCHEMBL2646354 | 0.79 | KCNH2 (0.79) | KCNH2GCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010039344-A1 | Heteroaromatic glucokinase activators | HOFFMANN-LA ROCHE INC. | 2001-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010039344-A1 | Heteroaromatic glucokinase activators | GCKR, GCK, PDXK | KCNH2 1062/4885GCK 2/4885ALDH1A1 3111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.