SCHEMBL7800825

SCHEMBL7800825

CC1(N)C=CC(N)C(c2cccs2)=C1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HSD17B10 Q99714 1/20 0.33
KCNH2 Q12809 1/20 0.33
CHRM2 P08172 1/20 0.33
CHRM4 P08173 1/20 0.33
CHRM5 P08912 1/20 0.33
CHRM1 P11229 1/20 0.33
CHRM3 P20309 1/20 0.33
GAA P10253 1/20 0.33
MAPK1 P28482 1/20 0.33
HPGD P15428 2/20 0.32
LPL P06858 1/20 0.32
LIPG Q9Y5X9 1/20 0.32
KDM4E B2RXH2 2/20 0.31
ALDH1A1 P00352 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7812052 0.83 HSD17B10 (0.34) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7807618 0.70 TDP1 (0.31) TDP1
SCHEMBL30631871 0.59 HPGD (0.47) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL16291133 0.59 L3MBTL1 (0.57) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL3545 0.59 L3MBTL1 (0.57) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7227898 0.57 L3MBTL1 (0.50) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9909950 0.57 HTR2C (0.38) NPC1CYP3A4CYP2C9HSD17B10KCNH2
Ethylamine SCHEMBL29134036 0.57 LTA4H (0.57) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
Fluoride SCHEMBL491501 0.57 L3MBTL1 (0.55) NPC1CYP1A2CYP3A4CYP2D6CYP2C9
Ammonia Solution, Strong SCHEMBL34467257 0.57 L3MBTL1 (0.55) NPC1CYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0943614-B1 Dyeing agents comprising diaminobenzene derivatives and the diaminobenzene derivatives WELLA AG (DE) 2001-12-12 EP disclosed
US-6042620-A FOR DYEING KERATIN FIBERS SUCH AS HAIR WELLA AG (DE) 2000-03-28 US disclosed
EP-0943614-A2 Dyeing agents comprising diaminobenzene derivatives and the diaminobenzene derivatives Wella Aktiengesellschaft (DE) 1999-09-22 EP disclosed