Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ZDHHC20 | Q5W0Z9 | 1/20 | 0.35 |
| ▸ | ZDHHC2 | Q9UIJ5 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL183843 | 0.96 | — | — | |
| SCHEMBL28062140 | 0.82 | ALDH1A1 (0.42) | ALDH1A1TSHRMAPK1TDP1KMT2A | |
| SCHEMBL13945600 | 0.78 | ALDH1A1 (0.46) | ALDH1A1TSHRMAPK1TDP1KMT2A | |
| SCHEMBL1681822 | 0.77 | ALDH1A1 (0.45) | ALDH1A1TSHRMAPK1TDP1KMT2A | |
| SCHEMBL368181 | 0.77 | SMN1; SMN2 (0.58) | ALDH1A1KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL14780157 | 0.76 | ALDH1A1 (0.48) | ALDH1A1TSHRMAPK1TDP1KMT2A | |
| SCHEMBL15753734 | 0.75 | SMN1; SMN2 (0.53) | ALDH1A1KMT2AHPGDSMN1; SMN2RAB9A | |
| SCHEMBL3832969 | 0.74 | — | — | |
| SCHEMBL3832973 | 0.74 | — | — | |
| SCHEMBL16197619 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951496-B1 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA PACIFIC RESINS (US) | 2001-12-19 | — | — | EP | disclosed |
| EP-0951496-A2 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA-PACIFIC RESINS, INC. (US) | 1999-10-27 | — | — | EP | disclosed |
| WO-1998030596-A2 | ALKYD AND ARALKYD DERIVATIVES OF PHENOLIC POLYMERS | GEORGIA-PACIFIC RESINS, INC. (US) | 1998-07-16 | — | — | WO | disclosed |
| US-5770750-A | Alkyd and aralkyd derivatives of phenolic polymers | GEORGIA-PACIFIC RESINS, INC. (US) | 1998-06-23 | — | — | US | disclosed |