Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | WDR5 | P61964 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30020102 | 0.85 | MAPT (0.69) | MAPTALDH1A1SIRT6CYP1A2CYP2D6 | |
| SCHEMBL12312120 | 0.85 | SIRT6 (0.64) | MAPTALDH1A1SIRT6CYP1A2CYP2D6 | |
| SCHEMBL23153821 | 0.82 | SIRT6 (0.58) | MAPTALDH1A1SIRT6CYP1A2CYP2D6 | |
| SCHEMBL29847854 | 0.81 | MAPT (0.76) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL30913088 | 0.81 | MAPT (0.72) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL15800716 | 0.81 | MAPT (0.72) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL16513593 | 0.81 | MAPT (0.76) | MAPTALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL22028444 | 0.77 | SIRT6 (0.61) | MAPTALDH1A1SIRT6CYP1A2CYP2D6 | |
| SCHEMBL30965662 | 0.76 | MAPT (0.52) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL31487397 | 0.76 | MAPT (0.52) | MAPTALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0533268-B1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LTD (GB) | 2001-08-16 | — | — | EP | disclosed |
| US-5510350-A | USEFUL IN TREATMENT OR PROPHYLAXIS OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS | GLAXO GROUP LIMITED (GB) | 1996-04-23 | — | — | US | disclosed |
| US-5358948-A | Psychological, nervous system disorders | GLAXCO GROUP LIMITED (GB) | 1994-10-25 | — | — | US | disclosed |
| US-5340810-A | Useful in the treatment and prophylaxis of depression and other disorders of the central nervous system | GLAXO GROUP LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |
| WO-1993006084-A1 | BENZANILIDE DERIVATIVES AS 5-HT1D ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
| EP-0533267-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| EP-0533268-A1 | Benzanilide derivatives as 5-HT1D antagonists | GLAXO GROUP LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |