Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KLK7 | P49862 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7801526 | 1.00 | LTA4H (0.45) | LTA4HKDM4EPOLBALDH1A1RAB9A | |
| Ornithine Aketoglutarate SCHEMBL7792959 | 0.97 | KDM4E (0.44) | LTA4HKDM4EPOLBALDH1A1RAB9A | |
| Ornithine SCHEMBL7792961 | 0.97 | KDM4E (0.44) | LTA4HKDM4EPOLBALDH1A1RAB9A | |
| Lysine SCHEMBL7800261 | 0.93 | KDM4E (0.48) | LTA4HKDM4EPOLBALDH1A1RAB9A | |
| Lysine SCHEMBL7798100 | 0.93 | LTA4H (0.44) | LTA4HKDM4EALDH1A1SMN1; SMN2DPP8 | |
| Lysine SCHEMBL7798098 | 0.93 | LTA4H (0.44) | LTA4HKDM4EALDH1A1SMN1; SMN2DPP8 | |
| P-Anisic Acid SCHEMBL7798469 | 0.91 | LTA4H (0.46) | LTA4HKDM4EALDH1A1RAB9AMAPT | |
| P-Anisic Acid SCHEMBL7798467 | 0.91 | LTA4H (0.46) | LTA4HKDM4EALDH1A1RAB9AMAPT | |
| Ornithine SCHEMBL8037246 | 0.91 | KDM4E (0.49) | LTA4HKDM4EPOLBALDH1A1RAB9A | |
| Phenylacetic Acid SCHEMBL7798111 | 0.91 | LTA4H (0.42) | LTA4HKDM4EPOLBALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |