Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 3/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.41 |
| ▸ | GRM6 | O15303 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylacetic Acid SCHEMBL7800189 | 0.95 | MC4R (0.42) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Phenylacetic Acid SCHEMBL7800193 | 0.95 | MC4R (0.42) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Phenylacetic Acid SCHEMBL8039166 | 0.90 | CCR5 (0.39) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Phenylacetic Acid SCHEMBL7802488 | 0.90 | CCR5 (0.39) | MC4RGRIK1GRIK2GRM8GRM4 | |
| D-Ornithine SCHEMBL7802026 | 0.89 | MC4R (0.45) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Ornithine Aketoglutarate SCHEMBL7802029 | 0.89 | MC4R (0.45) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Lysine SCHEMBL7800670 | 0.87 | MC4R (0.40) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Lysine SCHEMBL7800671 | 0.87 | MC4R (0.40) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Lysine SCHEMBL7792526 | 0.87 | GSR (0.50) | MC4RGRIK1GRIK2GRM8GRM4 | |
| Lysine SCHEMBL7798320 | 0.86 | MC4R (0.47) | MC4RGRIK1GRIK2GRM8GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |