Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 4/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRM8 | O00222 | 2/20 | 0.35 |
| ▸ | GRM6 | O15303 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7800671 | 1.00 | MC4R (0.40) | MC4RCCR5MMP2GRIK1GRIK2 | |
| Phenylacetic Acid SCHEMBL7802488 | 0.97 | CCR5 (0.39) | MC4RCCR5GRIK1GRIK2ALDH1A1 | |
| Phenylacetic Acid SCHEMBL8039166 | 0.97 | CCR5 (0.39) | MC4RCCR5GRIK1GRIK2ALDH1A1 | |
| Lysine SCHEMBL7803083 | 0.92 | MMP2 (0.43) | MC4RMMP2GRIK1GRIK2ALDH1A1 | |
| Lysine SCHEMBL7803085 | 0.92 | MMP2 (0.43) | MC4RMMP2GRIK1GRIK2ALDH1A1 | |
| Lysine SCHEMBL7803172 | 0.90 | CPB2 (0.40) | CCR5MMP2ALDH1A1SMN1; SMN2POLB | |
| Lysine SCHEMBL7803170 | 0.90 | CPB2 (0.40) | CCR5MMP2ALDH1A1SMN1; SMN2POLB | |
| Lysine SCHEMBL8025522 | 0.90 | MMP2 (0.41) | MC4RCCR5MMP2GRIK1GRIK2 | |
| Lysine SCHEMBL7803175 | 0.90 | MMP2 (0.39) | MC4RCCR5MMP2GRIK1GRIK2 | |
| Lysine SCHEMBL7798206 | 0.89 | NPBWR1 (0.36) | MC4RCCR5MMP2GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |