Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7801684 | 1.00 | LTA4H (0.43) | LTA4HSLC1A3SLC1A2SLC1A1HDAC3 | |
| Ornithine Aketoglutarate SCHEMBL7800197 | 0.98 | LTA4H (0.44) | LTA4HSLC1A3SLC1A2SLC1A1HDAC3 | |
| Ornithine SCHEMBL7800201 | 0.98 | LTA4H (0.44) | LTA4HSLC1A3SLC1A2SLC1A1HDAC3 | |
| Lysine SCHEMBL7798424 | 0.95 | LTA4H (0.47) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Lysine SCHEMBL7798422 | 0.95 | LTA4H (0.47) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Lysine SCHEMBL7802633 | 0.94 | MEN1 (0.42) | LTA4HSLC1A3SLC1A2SLC1A1HDAC3 | |
| Phenylacetic Acid SCHEMBL7802505 | 0.93 | LTA4H (0.48) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Phenylacetic Acid SCHEMBL7802503 | 0.93 | LTA4H (0.48) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Lysine SCHEMBL7798546 | 0.91 | LTA4H (0.46) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 | |
| Lysine SCHEMBL7798544 | 0.91 | LTA4H (0.46) | LTA4HSLC1A3SLC1A2SLC1A1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |