Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195043 | 0.88 | MAPT (0.67) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL5348283 | 0.85 | TDP1 (0.65) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL4362875 | 0.85 | ALDH1A1 (0.56) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL30060469 | 0.84 | MAPT (0.58) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL7807114 | 0.84 | MAPT (0.58) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL11015121 | 0.83 | MAPT (0.56) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL11715342 | 0.83 | MAPT (0.56) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL1373865 | 0.83 | HSPB1 (0.57) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL11012447 | 0.83 | MAPT (0.60) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL11655847 | 0.83 | MAPT (0.56) | MAPTALDH1A1LMNATDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820990-B1 | Benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR (FR) | 2001-01-17 | — | — | EP | disclosed |
| US-5972968-A | INTERLEUKIN INHIBITOR | ADIR ET COMPAGNIE (FR) | 1999-10-26 | — | — | US | disclosed |
| EP-0820990-A2 | Novel benzimidazole, benzoxazole, and benzothiazole derivatives useful as interleukin 1beta inhibitors | ADIR ET COMPAGNIE (FR) | 1998-01-28 | — | — | EP | disclosed |