Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.54 |
| ▸ | HTR1D | P28221 | 8/20 | 0.54 |
| ▸ | HTR1B | P28222 | 8/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.52 |
| ▸ | ACHE | P22303 | 2/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6308893 | 0.81 | HTR1A (0.50) | HTR1AHTR1DHTR1BCHEK1ACHE | |
| SCHEMBL6308994 | 0.78 | HTR1A (0.54) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL7800739 | 0.78 | HTR1A (0.49) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL6313735 | 0.77 | HTR1A (0.59) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL6314991 | 0.76 | HTR1A (0.64) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL3087242 | 0.74 | HRH4 (0.53) | HTR1AHTR1DCHEK1ACHEKCNH2 | |
| SCHEMBL6306333 | 0.72 | HTR1A (0.60) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL27394523 | 0.72 | HTR1A (0.53) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL6314228 | 0.71 | HTR1A (0.59) | HTR1AHTR1DHTR1BSLC6A9KCNH2 | |
| SCHEMBL6313298 | 0.70 | HTR1A (0.63) | HTR1AHTR1DHTR1BACHEUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20010004669-A1 | Pyrazinyl-substituted naphthalene derivatives | CHENARD BERTRAND L (US) | 2001-06-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010004669-A1 | Pyrazinyl-substituted naphthalene derivatives | HTR4, HCRTR2, CNR2 | HTR1A 13/4885HTR1D 22/4885HTR1B 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.