Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | LTA4H | P09960 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ornithine SCHEMBL7801571 | 0.97 | KDM4E (0.46) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Lysine SCHEMBL7800420 | 0.94 | LTA4H (0.48) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Lysine SCHEMBL7800419 | 0.94 | LTA4H (0.48) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Lysine SCHEMBL7802577 | 0.92 | ENPP2 (0.41) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Lysine SCHEMBL7802575 | 0.92 | ENPP2 (0.41) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Ornithine Aketoglutarate SCHEMBL7799956 | 0.91 | LTA4H (0.49) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Ornithine SCHEMBL7799957 | 0.91 | LTA4H (0.49) | KDM4EPOLBSMN1; SMN2LMNAMTNR1A | |
| Lysine SCHEMBL7802695 | 0.90 | LTA4H (0.46) | KDM4ESMN1; SMN2LTA4HALDH1A1MAPT | |
| Lysine SCHEMBL7802633 | 0.90 | MEN1 (0.42) | KDM4ELTA4HALDH1A1MAPTMEN1 | |
| P-Anisic Acid SCHEMBL7792587 | 0.90 | LTA4H (0.43) | KDM4EPOLBMTNR1AMTNR1BLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |