Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.44 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.38 |
| ▸ | GSR | P00390 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL7802706 | 1.00 | LTA4H (0.44) | LTA4HLTB4RLTB4R2METAP2ITGB3 | |
| Phenylacetic Acid SCHEMBL7802617 | 0.97 | LTB4R (0.44) | LTA4HLTB4RLTB4R2METAP2ITGB3 | |
| Phenylacetic Acid SCHEMBL7802615 | 0.97 | LTB4R (0.44) | LTA4HLTB4RLTB4R2METAP2ITGB3 | |
| Lysine SCHEMBL7798620 | 0.95 | LTA4H (0.47) | LTA4HMETAP2ITGB3ITGA2BNPC1 | |
| Lysine SCHEMBL7798616 | 0.95 | LTA4H (0.47) | LTA4HMETAP2ITGB3ITGA2BNPC1 | |
| Lysine SCHEMBL7792976 | 0.94 | LTA4H (0.45) | LTA4HLTB4RLTB4R2ITGB3ITGA2B | |
| Lysine SCHEMBL7792973 | 0.94 | LTA4H (0.45) | LTA4HLTB4RLTB4R2ITGB3ITGA2B | |
| Lysine SCHEMBL7798394 | 0.93 | LTA4H (0.44) | LTA4HLTB4RLTB4R2ITGB3ITGA2B | |
| Lysine SCHEMBL7798391 | 0.93 | LTA4H (0.44) | LTA4HLTB4RLTB4R2ITGB3ITGA2B | |
| Ornithine Aketoglutarate SCHEMBL7798085 | 0.92 | LTA4H (0.45) | LTA4HMETAP2ITGB3ITGA2BNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076649-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 2001-02-21 | — | — | EP | disclosed |
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |
| WO-1999055679-A1 | ISOQUINOLINE COMPOUND MELANOCORTIN RECEPTOR LIGANDS AND METHODS OF USING SAME | TREGA BIOSCIENCES, INC. (US) | 1999-11-04 | — | — | WO | disclosed |