Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.66 |
| ▸ | FBP1 | P09467 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | KDR | P35968 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.66 |
| ▸ | TEK | Q02763 | 1/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.66 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28403915 | 0.86 | EGFR (0.74) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL12788058 | 0.83 | EGFR (0.72) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL7802281 | 0.82 | EGFR (0.67) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL2991661 | 0.81 | EGFR (0.75) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL7814811 | 0.81 | EGFR (0.89) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL7811745 | 0.81 | EGFR (0.64) | EGFRERBB2 | |
| SCHEMBL5843772 | 0.80 | EGFR (0.69) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL8311292 | 0.80 | EGFR (0.77) | EGFRFBP1AURKAERBB2INSR | |
| Hydrochloric Acid SCHEMBL7811119 | 0.80 | EGFR (0.87) | EGFRFBP1AURKAERBB2INSR | |
| SCHEMBL8310628 | 0.80 | EGFR (0.67) | EGFRFBP1AURKAERBB2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635498-B1 | Quinazoline derivatives and their use as anti-cancer agents | SYNGENTA LTD (GB) | 2001-04-18 | — | — | EP | disclosed |
| US-5475001-A | Quinazoline derivatives | ZENECA LIMITED (GB) | 1995-12-12 | — | — | US | disclosed |
| WO-1995003283-A1 | QUINAZOLINE DERIVATIVES AND THEIR USE AS ANTI-CANCER AGENTS | ZENECA LIMITED (GB) | 1995-02-02 | — | — | WO | disclosed |
| EP-0635498-A1 | Quinazoline derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |