Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | DRD3 | P35462 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGDS | O60760 | 1/20 | 0.56 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.55 |
| ▸ | HTR3B | O95264 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | HTR6 | P50406 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344837 | 0.86 | DRD2 (0.63) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL30747784 | 0.84 | TSHR (0.68) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL4081243 | 0.84 | CYP2C19 (0.69) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL8362372 | 0.84 | TSHR (0.68) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL27829788 | 0.81 | AKR1C3 (0.83) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL16026545 | 0.81 | PKM (0.74) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL3252759 | 0.81 | PKM (0.78) | ALDH1A1TSHRPKMAKR1C3LMNA | |
| SCHEMBL7793932 | 0.79 | AKR1C3 (0.68) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL3904994 | 0.79 | KMT2A (0.68) | DRD2DRD3ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL12781882 | 0.79 | TSHR (0.73) | ALDH1A1TSHRPKMAKR1C3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018465-A9 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-09-15 | — | — | WO | disclosed |
| WO-2004018465-A2 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |
| EP-1075469-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 2001-02-14 | — | — | EP | disclosed |
| WO-2000052001-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 2000-09-08 | — | — | WO | disclosed |
| CN-86103798-A | The preparation method of N-phenyl-4-phenyl-1-piperazine carbonamidine and their purposes as anti-arrhythmic | — | 1987-06-10 | — | — | CN | disclosed |