Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | DRD3 | P35462 | 4/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.48 |
| ▸ | HTR7 | P34969 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8037884 | 0.99 | SLC6A2 (0.49) | SLC6A2SLC6A3SIGMAR1HTR2ASLC6A4 | |
| SCHEMBL15748030 | 0.85 | HTR2A (0.59) | SLC6A2SLC6A3SIGMAR1HTR2ASLC6A4 | |
| SCHEMBL7808859 | 0.84 | DRD2 (0.51) | SLC6A2SLC6A3SIGMAR1HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL8035305 | 0.83 | DRD2 (0.50) | SIGMAR1HTR2ASLC6A4DRD2DRD3 | |
| SCHEMBL7804944 | 0.80 | DRD2 (0.51) | SLC6A2SLC6A3SIGMAR1HTR2ASLC6A4 | |
| SCHEMBL7798311 | 0.80 | HTR1D (0.48) | HTR2ADRD3HTR2C | |
| Hydrochloric Acid SCHEMBL8021813 | 0.80 | DRD2 (0.50) | SIGMAR1HTR2ASLC6A4DRD2DRD3 | |
| Hydrochloric Acid SCHEMBL8021858 | 0.79 | HTR1D (0.47) | HTR2ADRD3HTR2C | |
| SCHEMBL7804951 | 0.77 | HTR1D (0.53) | SLC6A2SLC6A3SIGMAR1HTR2ASLC6A4 | |
| SCHEMBL11465528 | 0.77 | SIGMAR1 (0.76) | SIGMAR1HTR2ADRD2DRD3ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |