Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 5/20 | 0.44 |
| ▸ | HTR1B | P28222 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8031546 | 0.99 | HTR1D (0.44) | HTR1DHTR1BKDM4ESMN1; SMN2BRD4 | |
| SCHEMBL7804919 | 0.86 | KDM4E (0.41) | KDM4ESMN1; SMN2BRD4SIGMAR1L3MBTL1 | |
| SCHEMBL7804960 | 0.86 | HTR1D (0.44) | HTR1DHTR1BKDM4ESMN1; SMN2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8036973 | 0.85 | KDM4E (0.41) | KDM4ESMN1; SMN2BRD4SIGMAR1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8033560 | 0.85 | HTR1D (0.43) | HTR1DHTR1BKDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL7804169 | 0.81 | HTR1D (0.46) | HTR1DHTR1BKDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL7804076 | 0.81 | HTR1D (0.44) | HTR1DHTR1BKDM4ESIGMAR1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL7805955 | 0.81 | HTR1D (0.38) | HTR1DHTR1B | |
| Hydrochloric Acid SCHEMBL8021805 | 0.80 | HTR1D (0.45) | HTR1DHTR1BKDM4ESMN1; SMN2SIGMAR1 | |
| SCHEMBL7798125 | 0.80 | HTR1D (0.56) | HTR1DHTR1BKDM4EBRD4SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |