Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.45 |
| ▸ | DRD4 | P21917 | 4/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 4/20 | 0.43 |
| ▸ | DRD1 | P21728 | 4/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 2/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8031163 | 0.99 | KCNH2 (0.49) | KCNH2POLBSLC6A4SLC6A2DRD3 | |
| SCHEMBL7806971 | 0.86 | DRD3 (0.60) | KCNH2DRD3DRD2DRD4HTR1A | |
| SCHEMBL7798125 | 0.86 | HTR1D (0.56) | DRD3DRD2DRD4HRH1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8031131 | 0.85 | DRD3 (0.59) | KCNH2DRD3DRD2DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL8035289 | 0.85 | HTR1D (0.55) | DRD3DRD2DRD4HRH1SIGMAR1 | |
| SCHEMBL7805927 | 0.82 | HTR7 (0.50) | DRD3DRD2DRD4HTR7HTR1D | |
| SCHEMBL7804093 | 0.81 | HTR1D (0.54) | DRD3DRD2DRD4HTR2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL8021825 | 0.81 | HTR7 (0.49) | DRD3DRD2DRD4HTR7HTR1D | |
| Hydrochloric Acid SCHEMBL8021793 | 0.81 | HTR1D (0.53) | DRD3DRD2DRD4HTR2ASIGMAR1 | |
| SCHEMBL7805912 | 0.79 | HTR1D (0.51) | DRD3DRD2DRD4SIGMAR1HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |