Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMG1 | Q96Q15 | 11/20 | 0.91 |
| ▸ | CDK1 | P06493 | 4/20 | 0.91 |
| ▸ | CDK2 | P24941 | 4/20 | 0.91 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.71 |
| ▸ | MTOR | P42345 | 5/20 | 0.68 |
| ▸ | JAK2 | O60674 | 2/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.55 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | BCR | P11274 | 1/20 | 0.52 |
| ▸ | PRKCA | P17252 | 1/20 | 0.52 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107663 | 0.95 | SMG1 (1.00) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL6109641 | 0.83 | SMG1 (0.78) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL12274500 | 0.79 | CAMK2D (0.81) | SMG1CDK1CDK2CAMK2DJAK2 | |
| SCHEMBL6608384 | 0.78 | SMG1 (0.69) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL6093874 | 0.78 | SMG1 (0.69) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL6095801 | 0.77 | SMG1 (0.68) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL6109026 | 0.77 | CSNK2A1 (0.69) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL27580808 | 0.76 | SMG1 (0.66) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL6093641 | 0.76 | SMG1 (0.66) | SMG1CDK1CDK2CAMK2DMTOR | |
| SCHEMBL7811447 | 0.75 | CSNK2A1 (0.72) | SMG1CDK1CDK2CAMK2DMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0672041-B1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | NOVARTIS AG (CH) | 2001-11-14 | — | — | EP | disclosed |
| EP-0672041-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Novartis AG (CH) | 1995-09-20 | — | — | EP | disclosed |
| WO-1995009853-A1 | PHARMACOLOGICALLY ACTIVE PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | CIBA-GEIGY AG (CH) | 1995-04-13 | — | — | WO | disclosed |