Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.39 |
| ▸ | CES1 | P23141 | 2/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 3/20 | 0.31 |
| ▸ | RPS6KA1 | Q15418 | 3/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087773 | 1.00 | CES2 (0.39) | CES2CES1TRPM8ADRB2PDE2A | |
| SCHEMBL7795357 | 1.00 | CES2 (0.39) | CES2CES1TRPM8ADRB2PDE2A | |
| Hydrochloric Acid SCHEMBL7787841 | 0.97 | CES2 (0.38) | CES2CES1TRPM8ADRB2PDE2A | |
| Hydrochloric Acid SCHEMBL7787647 | 0.97 | CES2 (0.38) | CES2CES1TRPM8ADRB2PDE2A | |
| SCHEMBL12563296 | 0.82 | ADRB2 (0.36) | TRPM8ADRB2PDE2ADPP4AKT1 | |
| SCHEMBL5380674 | 0.82 | ADRB2 (0.39) | ADRB2PDE2ADPP4 | |
| SCHEMBL19654073 | 0.82 | ADRB2 (0.36) | TRPM8ADRB2PDE2ADPP4AKT1 | |
| SCHEMBL5721005 | 0.82 | ADRB2 (0.39) | ADRB2PDE2ADPP4 | |
| SCHEMBL19654075 | 0.82 | ADRB2 (0.36) | TRPM8ADRB2PDE2ADPP4AKT1 | |
| SCHEMBL17041213 | 0.80 | KDM1A (0.38) | ADRB2PDE2ADPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2681215-B1 | SERINE/THREONINE KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2015-04-22 | — | — | EP | claimed |
| EP-1070703-A1 | Cyclobutene derivatives | Sankyo Company Limited (JP) | 2001-01-24 | — | — | EP | disclosed |