Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11741957 | 0.78 | LMNA (0.47) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL8067542 | 0.78 | LMNA (0.47) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL2318768 | 0.78 | LMNA (0.65) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL1268961 | 0.78 | LMNA (0.65) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5409561 | 0.78 | LMNA (0.65) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL14167936 | 0.77 | PRMT5 (0.49) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL9060321 | 0.76 | LMNA (0.63) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL5093206 | 0.76 | LOXL2 (0.50) | ALDH1A1LMNATSHRKMT2ALOXL2 | |
| SCHEMBL11743526 | 0.76 | LMNA (0.44) | USP2ALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL11745695 | 0.75 | LMNA (0.47) | USP2ALDH1A1HPGDHSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636623-B1 | Indole derivatives as 5-HT1- like agonists | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| US-6103752-A | PHTHALIMIDE DERIVATIVE AS HT3 RECEPTOR ANTAGONIST | GLAXO WELLCOME INC. (US) | 2000-08-15 | — | — | US | disclosed |
| US-5922748-A | TREATMENT OF HEADACHES AND MIGRAINES | GLAXO WELLCOME INC. (US) | 1999-07-13 | — | — | US | disclosed |
| US-5863935-A | SYNTHESIS OF INDOLE DERIVATIVES OF HETEROCYCLIC COMPOUNDS FOR TREATMENT OF HEADACHES AND MIGRAINES | ZENECA LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |
| US-5744466-A | ANTISEROTONIN AGENT | THE WELLCOME FOUNDATION LIMITED (GB) | 1998-04-28 | — | — | US | disclosed |
| CN-1143960-A | Therapeutic heterocyclic compounds | WELLCOME FOUND (GB) | 1997-02-26 | — | — | CN | disclosed |
| EP-0741725-A1 | INDOLE DERIVATIVES AS 5-HT 1? AGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| US-5466699-A | Indolyl compounds for treating migraine | BURROUGHS WELLCOME CO. (US) | 1995-11-14 | — | — | US | disclosed |
| WO-1995020588-A1 | INDOLE DERIVATIVES AS 5-HT1 AGONISTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |
| US-5399574-A | 5-hydroxytryptamine agonists; vasoconstrictors | BURROUGHS WELLCOME CO. (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0636623-A1 | Indole derivatives as 5-HT1- like agonists | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0486666-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS. | WELLCOME FOUND (GB) | 1992-05-27 | — | — | EP | disclosed |
| WO-1991018897-A1 | THERAPEUTIC HETEROCYCLIC COMPOUNDS | THE WELLCOME FOUNDATION LIMITED (GB) | 1991-12-12 | — | — | WO | disclosed |