Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 4/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815368 | 0.92 | KDM4E (0.54) | NCF1SLC2A1KDM4EALDH1A1HPGD | |
| SCHEMBL6607915 | 0.87 | SLC2A1 (0.62) | SLC2A1KDM4ESYKALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6607447 | 0.86 | SLC2A1 (0.61) | SLC2A1KDM4ESYKALDH1A1HPGD | |
| SCHEMBL7812693 | 0.83 | SLC2A1 (0.61) | SLC2A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7805481 | 0.82 | SLC2A1 (0.60) | SLC2A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL7805413 | 0.76 | NCF1 (0.76) | NCF1ALDH1A1TLR8 | |
| SCHEMBL27565798 | 0.75 | KDM4E (0.51) | NCF1SLC2A1KDM4EALDH1A1HPGD | |
| SCHEMBL10401114 | 0.73 | SMN1; SMN2 (0.60) | ALDH1A1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL10852857 | 0.72 | SLC2A1 (0.39) | NCF1SLC2A1KDM4EALDH1A1HPGD | |
| SCHEMBL423902 | 0.71 | CYP1A2 (0.55) | NCF1TLR8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6320051-B1 | AMINO(NH) OR OXYGEN(O) SUBSTITUTED, ENZYME INHIBITORS OF STAPHLOCCOCUS AUREUS METHIONYL T-RNA SYNTHETASE (MRS); ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2001-11-20 | — | — | US | disclosed |
| EP-1084110-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 2001-03-21 | — | — | EP | disclosed |
| WO-2000021949-A1 | QUINOLONES AS T-RNA SYNTHETASE INHIBITORS AND ANTIBACTERIAL AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-04-20 | — | — | WO | disclosed |
| WO-1999055677-A1 | QUINOLONES USED AS MRS INHIBITORS AND BACTERICIDES | SMITHKLINE BEECHAM PLC (GB) | 1999-11-04 | — | — | WO | disclosed |