Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 6/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.39 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966126 | 0.81 | CETP (0.52) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL13713688 | 0.81 | CARM1 (0.49) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL12932842 | 0.77 | CARM1 (0.50) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL29373647 | 0.73 | PRMT6 (0.59) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL8348536 | 0.73 | PRMT6 (0.59) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL169092 | 0.72 | CARM1 (0.49) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL7805544 | 0.72 | CETP (0.57) | MAPK14CETPROCK1ROCK2KDM5A | |
| SCHEMBL22957820 | 0.72 | CARM1 (0.44) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL12963217 | 0.71 | CHRM2 (0.51) | MAPK14CETPCARM1PRMT6ROCK1 | |
| SCHEMBL1416997 | 0.71 | CETP (0.56) | MAPK14CETPCHRM2CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115693-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | Monsanto Company (US) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018721-A1 | SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL TERTIARY-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY | MONSANTO COMPANY (US) | 2000-04-06 | — | — | WO | disclosed |