SCHEMBL780642

SCHEMBL780642

c1ccc(-c2c3ccccc3c(-c3cccc(-n4c5cc(-c6cccc7c6sc6c(-c8ccccc8)cccc67)ccc5c5ccc(-c6cccc7c6sc6c(-c8ccccc8)cccc67)cc54)c3)c3ccccc23)cc1

nearest known ligand 0.38

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.38
LIMK1 P53667 1/20 0.36
KDM4E B2RXH2 1/20 0.34
ATM Q13315 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
PDE10A Q9Y233 1/20 0.32
PRKDC P78527 1/20 0.32
KMT2A Q03164 2/20 0.31
MEN1 O00255 1/20 0.30
GAA P10253 1/20 0.30
F9 P00740 1/20 0.30
ENPP1 P22413 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL780623 0.98 KDM4E (0.39) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780795 0.95 ALOX5 (0.36) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780646 0.93 KDM4E (0.37) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780621 0.93 ALOX5 (0.38) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780891 0.93 ALOX5 (0.39) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780763 0.92 ALOX5 (0.49) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780700 0.92 KDM4E (0.40) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL781070 0.91 ALOX5 (0.39) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL780630 0.91 KDM4E (0.37) ALOX5LIMK1KDM4EATML3MBTL1
SCHEMBL781027 0.91 ALOX5 (0.36) ALOX5LIMK1KDM4EATML3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-12-29 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-9450188-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2016-09-20 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-20140145175-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-05-29 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-8642782-B2 Carbazole derivative, light-emitting element material and organic semiconductor material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. (JP) 2014-02-04 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SEMICONDUCTOR ENERGY LABORATORY CO., LTD. 2012-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160380211-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 ALOX5 1162/4885LIMK1 3472/4885KDM4E 3917/4885
US-20120071668-A1 Carbazole Derivative, Light-Emitting Element Material and Organic Semiconductor Material SLC39A3, SULT1A1, NUTF2 ALOX5 1162/4885LIMK1 3472/4885KDM4E 3917/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.