Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.58 |
| ▸ | RAB9A | P51151 | 8/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13049170 | 0.80 | RAB9A (0.65) | NPC1RAB9AL3MBTL1ALDH1A1GLA | |
| SCHEMBL3785860 | 0.80 | F10 (0.79) | NPC1RAB9AL3MBTL1ALDH1A1GLA | |
| SCHEMBL30117892 | 0.80 | F10 (0.79) | NPC1RAB9AL3MBTL1ALDH1A1GLA | |
| SCHEMBL7814785 | 0.79 | TP53 (0.54) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL5183311 | 0.78 | GAA (0.66) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL11193309 | 0.77 | PLK1 (0.60) | NPC1RAB9AKMT2ASMN1; SMN2MEN1 | |
| SCHEMBL11146320 | 0.77 | MAPT (0.58) | NPC1RAB9AL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL5180990 | 0.77 | MAPT (0.64) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL22192224 | 0.77 | MAPT (0.64) | NPC1RAB9AALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL14252928 | 0.77 | MEN1 (0.79) | NPC1RAB9AL3MBTL1ALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077929-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999061410-A1 | 2,3,5-SUBSTITUTED BIPHENYLS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-02 | — | — | WO | disclosed |