SCHEMBL7806844

SCHEMBL7806844

CC(C)C(=O)OCC(O)(COC(=O)C(C)C)c1cccc2ccccc12

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.51
POLB P06746 1/20 0.51
MAPT P10636 1/20 0.51
KCNJ11 Q14654 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TDP1 Q9NUW8 2/20 0.39
KDM4E B2RXH2 2/20 0.39
KIF11 P52732 1/20 0.39
HPGD P15428 1/20 0.38
ADRB2 P07550 2/20 0.38
ADRB1 P08588 2/20 0.38
ADRB3 P13945 2/20 0.38
CDC25B P30305 1/20 0.38
ACP3 P15309 1/20 0.38
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
ATM Q13315 1/20 0.37
CNR2 P34972 1/20 0.36
CTNNB1 P35222 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8138829 0.92 ALDH1A1 (0.45) ALDH1A1POLBMAPTKCNJ11L3MBTL1
SCHEMBL7808592 0.80 ALDH1A1 (0.58) ALDH1A1POLBMAPTL3MBTL1TDP1
SCHEMBL7810074 0.79 ALDH1A1 (0.54) ALDH1A1POLBMAPTKIF11HPGD
SCHEMBL16124202 0.76 ALDH1A1 (0.42) ALDH1A1KCNJ11L3MBTL1TDP1KDM4E
SCHEMBL7809619 0.74 ALDH1A1 (0.51) ALDH1A1POLBMAPTL3MBTL1TDP1
SCHEMBL3169247 0.74 ALDH1A1 (0.35) ALDH1A1KCNJ11TDP1KDM4EKIF11
SCHEMBL7808447 0.73 ALDH1A1 (0.48) ALDH1A1POLBMAPTKIF11ADRB2
SCHEMBL8083878 0.73 SLC1A3 (0.52) ALDH1A1L3MBTL1TDP1KDM4EATM
SCHEMBL7813592 0.71 ALDH1A1 (0.48) ALDH1A1POLBMAPTL3MBTL1TDP1
SCHEMBL5655818 0.71 TDP1 (0.53) ALDH1A1L3MBTL1TDP1KDM4EATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1120397-A2 Process for preparing triazole derivative KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2001-08-01 EP disclosed
EP-0704419-B1 PROCESS FOR PRODUCING AN OPTICALLY ACTIVE 2-ARYL-3-ACYLOXY-1,2-PROPANEDIOL KANEGAFUCHI CHEMICAL IND (JP) 2001-07-25 EP disclosed
US-6046354-A CHEMICAL INTERMEDIATES, E.G. 2-ARYL-1,3-DIACYLOXY-2-PROPANOL, FOR DRUGS AND FUNGICIDES,E.G. (R)-2-(2,4-DIFLUOROPHENYL)-3-(1H-1,2,4-TRIAZOLE-1-YL)-PROPANE-1,2-DIOL, KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 2000-04-04 US disclosed
US-5840553-A OPTICALLY ACTIVE 2-ARYL-3-ACYLOXY-1,2,-PROPANE DIOL USING A MICROORGANISM OR ENZYME DERIVED FROM PORCINE PANCREAS; VIA STEREOSPECIFIC HYDROLYSIS OF A 2-ARYL-1,3-DIACYLOXY-2-PROPANOL; SYNTHETIC CHEMICAL INTERMEDIATES, FUNGICIDES KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1998-11-24 US disclosed
US-5654472-A OPTICALLY PURE 2-ARYL-3-ACYLOXY-1,2-PROPANEDIOL COMPOUNDS; CHEMICAL INTERMEDIATES KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1997-08-05 US disclosed
EP-0704419-A1 PROCESS FOR PRODUCING TRIAZOLE DERIVATIVE KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) 1996-04-03 EP disclosed