Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Fluorescin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | STAT6 | P42226 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | HBB | P68871 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | ESR1 | P03372 | 5/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluorescin SCHEMBL31214151 | 0.94 | CYP2C9 (0.71) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL31164674 | 0.94 | CYP2C9 (0.71) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL29370997 | 0.94 | CYP2C9 (0.71) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL31164673 | 0.94 | CYP2C9 (0.71) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL27403 | 0.94 | CYP2C9 (0.71) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL1938032 | 0.93 | CYP2C9 (0.69) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL1507667 | 0.93 | CYP2C9 (0.69) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL5579981 | 0.89 | CYP2C9 (0.64) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL4342272 | 0.89 | CYP2C9 (0.64) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 | |
| Fluorescin SCHEMBL6036317 | 0.88 | CYP2C9 (0.62) | CYP2C9HSD17B10ALDH1A1BRCA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161558-A1 | INTACT CELL ASSAY FOR PROTEIN TYROSINE PHOSPHATASES | Merck Frosst Canada & Co. (CA) | 2001-12-12 | — | — | EP | disclosed |
| US-6329137-B1 | Intact cell assay for protein tyrosine phosphatases using recombinant baculoviruses | MERCK FROSST CANADA & CO. (CA) | 2001-12-11 | — | — | US | disclosed |
| WO-2000053801-A1 | INTACT CELL ASSAY FOR PROTEIN TYROSINE PHOSPHATASES | MERCK FROSST CANADA & CO. (CA) | 2000-09-14 | — | — | WO | disclosed |