Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPT2 | P23786 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.37 |
| ▸ | ODC1 | P11926 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6911619 | 0.75 | CPT2 (0.37) | CPT2ACLYODC1KDM4ELMNA | |
| SCHEMBL6911617 | 0.75 | CPT2 (0.37) | CPT2ACLYODC1KDM4ELMNA | |
| SCHEMBL6348790 | 0.64 | ALDH1A1 (0.37) | ODC1KDM4ELMNAMAPTRAB9A | |
| SCHEMBL6913439 | 0.63 | CPT2 (0.35) | CPT2ACLY | |
| SCHEMBL679467 | 0.62 | ACLY (0.59) | CPT2ACLYBLM | |
| SCHEMBL29074266 | 0.62 | ACLY (0.54) | CPT2ACLYBLM | |
| SCHEMBL17656832 | 0.62 | ACLY (0.59) | CPT2ACLYBLM | |
| SCHEMBL4416232 | 0.62 | ACLY (0.59) | CPT2ACLYBLM | |
| SCHEMBL31629798 | 0.62 | ACLY (0.59) | CPT2ACLYBLM | |
| SCHEMBL18969113 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082110-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062506-A1 | USE OF COMPOUNDS FOR THE ELEVATION OF PYRUVATE DEHYDROGENASE ACTIVITY | ASTRAZENECA AB (SE) | 1999-12-09 | — | — | WO | disclosed |