Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 14/20 | 0.52 |
| ▸ | SMO | Q99835 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476455 | 0.94 | OPRK1 (0.61) | OPRK1MAPK14SMOCSF1RKDR | |
| SCHEMBL7807945 | 0.88 | OPRK1 (0.56) | OPRK1MAPK14SMONTRK1 | |
| SCHEMBL7804552 | 0.86 | OPRK1 (0.54) | OPRK1MAPK14SMONTRK1 | |
| SCHEMBL7806472 | 0.85 | OPRK1 (0.51) | OPRK1MAPK14SMONTRK1 | |
| SCHEMBL6978609 | 0.84 | MAPK14 (0.68) | MAPK14SMOCSF1R | |
| SCHEMBL7805580 | 0.83 | MAPK14 (0.56) | OPRK1MAPK14SMOCSF1RNTRK1 | |
| SCHEMBL7780464 | 0.83 | MAPK14 (0.65) | MAPK14SMO | |
| SCHEMBL6476258 | 0.82 | OPRK1 (0.62) | OPRK1MAPK14SMOCSF1RNTRK1 | |
| SCHEMBL7856914 | 0.82 | MAPK14 (0.70) | MAPK14 | |
| SCHEMBL6979521 | 0.82 | MAPK14 (0.58) | OPRK1MAPK14SMOCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077931-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | AstraZeneca AB (SE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999059959-A1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 1999-11-25 | — | — | WO | disclosed |