Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23318790 | 0.85 | GAA (0.42) | GAANPC1ALDH1A1MAPTPDE2A | |
| SCHEMBL11844851 | 0.84 | ALDH1A1 (0.41) | DYRK1AGAANPC1ALDH1A1MAPT | |
| SCHEMBL179444 | 0.84 | CYP2C19 (0.44) | DYRK1AGAANPC1ALDH1A1MAPT | |
| SCHEMBL13347572 | 0.82 | MAPT (0.50) | ALDH1A1MAPTPDE2AL3MBTL1CYP2C9 | |
| SCHEMBL1159995 | 0.82 | CA2 (0.46) | ALDH1A1CYP2C9CYP2C19MEN1POLB | |
| SCHEMBL22477432 | 0.78 | ALDH1A1 (0.55) | GAAALDH1A1MAPTL3MBTL1MEN1 | |
| SCHEMBL3535109 | 0.78 | ALDH1A1 (0.41) | DYRK1AGAANPC1ALDH1A1MAPT | |
| SCHEMBL24486537 | 0.78 | ALDH1A1 (0.44) | DYRK1AGAANPC1ALDH1A1MAPT | |
| SCHEMBL2796185 | 0.77 | TSHR (0.56) | PDE2ATSHRTAAR1CYP3A4 | |
| SCHEMBL11648542 | 0.77 | MAOB (0.53) | ALDH1A1MEN1HPGDMAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |