Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | SMO | Q99835 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 3/20 | 0.55 |
| ▸ | RAF1 | P04049 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2968436 | 0.93 | MAPK14 (0.82) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL7807977 | 0.89 | MAPK14 (0.78) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL6485519 | 0.87 | MAPK14 (0.89) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL7807923 | 0.86 | MAPK14 (0.85) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL7838866 | 0.86 | MAPK14 (0.65) | MAPK14BRAFRAF1DGAT1 | |
| SCHEMBL7856635 | 0.85 | MAPK14 (0.57) | MAPK14SMOBRAFRAF1 | |
| SCHEMBL6477445 | 0.84 | MAPK14 (1.00) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL7846779 | 0.84 | MAPK14 (0.60) | MAPK14SMOBRAFRAF1 | |
| SCHEMBL2345986 | 0.83 | KMT2A (0.67) | MAPK14KMT2AMEN1SMOMAPT | |
| SCHEMBL7846789 | 0.81 | MAPK14 (0.55) | MAPK14LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102743-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | AstraZeneca AB (SE) | 2001-05-30 | — | — | EP | disclosed |
| WO-2000007980-A1 | AMIDE DERIVATIVES WHICH ARE USEFUL AS CYTOKINE INHIBITORS | ASTRAZENECA AB (SE) | 2000-02-17 | — | — | WO | disclosed |