SCHEMBL7807992

SCHEMBL7807992

O=C1c2ccccc2C(=O)c2ncc(F)cc21

nearest known ligand 0.54

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.54
MAOB P27338 7/20 0.49
NPC1 O15118 3/20 0.49
RAB9A P51151 3/20 0.49
ALDH1A1 P00352 2/20 0.49
MAPT P10636 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
CASP3 P42574 1/20 0.49
SENP8 Q96LD8 1/20 0.49
SENP7 Q9BQF6 1/20 0.49
SENP6 Q9GZR1 1/20 0.49
MEN1 O00255 1/20 0.44
CDC25B P30305 1/20 0.44
PTPRC P08575 1/20 0.43
PKM P14618 1/20 0.42
AGTR1 P30556 1/20 0.42
MAOA P21397 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7808369 0.86 KMT2A (0.40) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL8917379 0.78 KMT2A (0.86) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL14416135 0.75 CES1 (0.52) KMT2AMAOBALDH1A1PKMMAOA
SCHEMBL19868510 0.74 KMT2A (0.50) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL19856524 0.74 KMT2A (0.50) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL30635316 0.73 S100A4 (0.53)
SCHEMBL7807690 0.73 KMT2A (0.35) KMT2AMAOBRAB9AALDH1A1MEN1
SCHEMBL3894758 0.71 MEN1 (0.57) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL1712951 0.70 KMT2A (0.64) KMT2AMAOBNPC1RAB9AALDH1A1
SCHEMBL19865965 0.70 KMT2A (0.50) KMT2AMAOBNPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0695752-B1 ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIV MADRID COMPLUTENSE (ES) 2001-06-06 EP disclosed
US-5716963-A DIAZAQUINOMYCIN DERIVATIVE UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1998-02-10 US disclosed
EP-0695752-A1 NEW ANTHRAQUINONIC DERIVATIVES HAVING AN ANTITUMOR ACTIVITY, AND APPLICATIONS THEREOF UNIVERSIDAD COMPLUTENSE DE MADRID (ES) 1996-02-07 EP disclosed