Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 3/20 | 0.59 |
| ▸ | CTSL | P07711 | 4/20 | 0.54 |
| ▸ | CTSS | P25774 | 4/20 | 0.54 |
| ▸ | CTSB | P07858 | 6/20 | 0.54 |
| ▸ | CTSK | P43235 | 6/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA5A | P35218 | 1/20 | 0.53 |
| ▸ | CTSD | P07339 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 2/20 | 0.51 |
| ▸ | CASP6 | P55212 | 2/20 | 0.51 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.51 |
| ▸ | CASP9 | P55211 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807991 | 1.00 | CASP3 (0.59) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL2228854 | 0.90 | ATM (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4394496 | 0.90 | ATM (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4394493 | 0.90 | ATM (0.56) | CTSLCTSSCTSBCTSK | |
| SCHEMBL19557810 | 0.85 | CASP3 (0.61) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL10453618 | 0.85 | CASP3 (0.61) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL23926088 | 0.85 | CTSB (0.71) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL14341580 | 0.85 | CTSB (0.71) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL5133312 | 0.85 | CTSB (0.71) | CASP3CTSLCTSSCTSBCTSK | |
| SCHEMBL13982783 | 0.85 | CASP3 (0.62) | CASP3CTSLCTSSCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0721449-B1 | INHIBITORS OF BETA-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMA INC (US) | 2001-12-19 | — | — | EP | disclosed |
| US-5977074-A | THERAPY FOR ALZHEIMER'S DISEASE | MERRELL PHARMACEUTICALS, INC. (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0721449-A1 | INHIBITORS OF $g(b)-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1996-07-17 | — | — | EP | disclosed |
| WO-1995009838-A1 | INHIBITORS OF β-AMYLOID PROTEIN PRODUCTION | MERRELL PHARMACEUTICALS INC. (US) | 1995-04-13 | — | — | WO | disclosed |