Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.69 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | RAB9A | P51151 | 4/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.63 |
| ▸ | CCR3 | P51677 | 1/20 | 0.61 |
| ▸ | LTA4H | P09960 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807819 | 0.92 | HRH3 (0.82) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL7995012 | 0.91 | HRH3 (0.83) | HRH3NPC1RAB9AKDM4EKMT2A | |
| SCHEMBL7811609 | 0.89 | NPC1 (0.78) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL7809890 | 0.89 | NPC1 (0.70) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL13149660 | 0.88 | HRH3 (0.78) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL31484892 | 0.88 | HRH3 (0.78) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL7812466 | 0.88 | NPC1 (0.68) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL7809854 | 0.86 | NPC1 (0.73) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL3039422 | 0.85 | HRH3 (0.68) | HRH3NPC1RAB9ATP53KDM4E | |
| SCHEMBL1143656 | 0.85 | NPC1 (0.85) | HRH3NPC1RAB9ATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |