Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.66 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | NPY1R | P25929 | 1/20 | 0.57 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7809890 | 0.96 | NPC1 (0.70) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7809854 | 0.91 | NPC1 (0.73) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7808301 | 0.88 | HRH3 (0.69) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7811609 | 0.87 | NPC1 (0.78) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7809622 | 0.86 | NPC1 (0.92) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL12040822 | 0.86 | CCR3 (0.64) | KDM4E | |
| SCHEMBL31484892 | 0.85 | HRH3 (0.78) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7808307 | 0.85 | NPC1 (0.89) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL7807819 | 0.85 | HRH3 (0.82) | NPC1RAB9ATP53ALDH1A1KDM4E | |
| SCHEMBL3039422 | 0.83 | HRH3 (0.68) | NPC1RAB9ATP53ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | claimed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | claimed |
| EP-1140880-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | AstraZeneca AB (SE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000039110-A1 | HOMOPIPERAZINE DERIVATIVES AS SELECTIVE EMOPAMIL INHIBITORS | ASTRAZENECA AB (SE) | 2000-07-06 | — | — | WO | disclosed |