SCHEMBL7808315

SCHEMBL7808315

COc1ccc(-c2nc3c(o2)C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP1 O94782 4/20 0.71
USP19 O94966 2/20 0.71
WDR48 Q8TAF3 1/20 0.71
UCHL3 P15374 1/20 0.68
USP2 O75604 2/20 0.58
USP8 P40818 2/20 0.58
OTUB1 Q96FW1 2/20 0.58
USP36 Q9P275 1/20 0.58
MAPT P10636 6/20 0.52
NPC1 O15118 5/20 0.52
RAB9A P51151 5/20 0.52
ALDH1A1 P00352 5/20 0.52
SMN1; SMN2 Q16637 4/20 0.52
KDM4E B2RXH2 2/20 0.52
LMNA P02545 1/20 0.52
CCNE2 O96020 1/20 0.50
CDK4 P11802 1/20 0.50
CCND1 P24385 1/20 0.50
CCNE1 P24864 1/20 0.50
CDK2 P24941 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7968066 0.84 USP1 (0.77) USP1USP19WDR48UCHL3USP2
SCHEMBL7808226 0.84 USP1 (1.00) USP1USP19WDR48UCHL3USP2
SCHEMBL29629184 0.84 USP1 (1.00) USP1USP19WDR48UCHL3USP2
SCHEMBL29629183 0.84 USP1 (1.00) USP1USP19WDR48UCHL3USP2
SCHEMBL31276578 0.81 USP1 (1.00) USP1USP19WDR48UCHL3USP2
SCHEMBL7808410 0.81 USP1 (0.77) USP1USP19WDR48UCHL3USP2
SCHEMBL19225117 0.81 USP1 (0.77) USP1USP19WDR48UCHL3USP2
SCHEMBL7815859 0.81 USP1 (1.00) USP1USP19WDR48UCHL3USP2
SCHEMBL19220486 0.81 USP1 (0.82) USP1USP19WDR48UCHL3USP2
SCHEMBL19198299 0.80 USP1 (0.61) USP1USP19WDR48UCHL3USP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876356-B1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF INNOTHERA SA LAB (FR) 2001-10-31 EP claimed
EP-0876356-B1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF INNOTHERA SA LAB (FR) 2001-10-31 EP disclosed
US-6262095-B1 TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA LABORATOIRE INNOTHERA (FR) 2001-07-17 US disclosed
EP-0876356-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA Société Anonyme (FR) 1998-11-11 EP disclosed
WO-1997021684-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) 1997-06-19 WO disclosed