Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6316045 | 0.87 | TSHR (0.58) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| SCHEMBL18765295 | 0.84 | KDM4E (0.63) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| SCHEMBL7953771 | 0.84 | TSHR (0.43) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| SCHEMBL3939111 | 0.81 | TSHR (0.46) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| SCHEMBL7367970 | 0.81 | TSHR (0.46) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| SCHEMBL5838645 | 0.77 | HSD17B10 (0.60) | TSHRKDM4ERAB9AHSD17B10TP53 | |
| SCHEMBL18765244 | 0.77 | GAA (0.57) | TSHRKMT2ARAB9AHSD17B10SMN1; SMN2 | |
| SCHEMBL7375901 | 0.77 | MEN1 (0.64) | KDM4EKMT2ARAB9ASMN1; SMN2TP53 | |
| SCHEMBL3895619 | 0.76 | BRD4 (0.49) | TSHRKDM4EKMT2ARAB9AHSD17B10 | |
| Hydrochloric Acid SCHEMBL18765408 | 0.76 | GAA (0.56) | TSHRKMT2ARAB9AHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140802-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM KG (DE) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035859-A1 | SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS MEDICINES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2000-06-22 | — | — | WO | disclosed |