Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7808323 | 0.84 | TSHR (0.46) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL6316045 | 0.83 | TSHR (0.58) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL18765295 | 0.77 | KDM4E (0.63) | TSHRLMNAKDM4ERAB9AHSD17B10 | |
| SCHEMBL5838645 | 0.77 | HSD17B10 (0.60) | TSHRALDH1A1KDM4ERAB9AHSD17B10 | |
| SCHEMBL8557058 | 0.75 | FFAR2 (0.41) | ALDH1A1LMNAKDM4ERAB9AHSD17B10 | |
| SCHEMBL7367970 | 0.75 | TSHR (0.46) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL3939111 | 0.75 | TSHR (0.46) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL391457 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KDM4ERAB9ASMN1; SMN2KMT2A | |
| SCHEMBL7749655 | 0.74 | ALDH1A1 (0.47) | TSHRPOLBALDH1A1LMNAKDM4E | |
| SCHEMBL18765244 | 0.73 | GAA (0.57) | TSHRALDH1A1LMNARAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235758-B1 | CENTRAL NERVOUS SYSTEM DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-05-22 | — | — | US | disclosed |
| EP-0808312-B1 | INDOLE DERIVATIVES AS 5-HT RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM PLC (GB) | 2000-11-02 | — | — | EP | disclosed |
| US-5990133-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS SUCH AS ANXIETY OR DEPRESSION | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | disclosed |