Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 9/20 | 0.50 |
| ▸ | TDO2 | P48775 | 6/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7814769 | 0.79 | IDO1 (0.55) | IDO1TDO2NPC1RAB9A | |
| SCHEMBL7808342 | 0.79 | IDO1 (0.55) | IDO1TDO2NPC1RAB9A | |
| SCHEMBL7811891 | 0.79 | IDO1 (0.55) | IDO1TDO2POLB | |
| SCHEMBL7813124 | 0.79 | IDO1 (0.55) | IDO1TDO2POLBNPC1RAB9A | |
| SCHEMBL7812948 | 0.77 | IDO1 (0.52) | IDO1TDO2BLMNPC1RAB9A | |
| SCHEMBL25028187 | 0.73 | MMP2 (0.46) | MMP2MMP9MMP8MMP13SLC2A1 | |
| SCHEMBL7816639 | 0.73 | IDO1 (0.57) | IDO1TDO2POLBBLMMAOB | |
| SCHEMBL7805846 | 0.73 | IDO1 (0.48) | IDO1TDO2POLBNPC1RAB9A | |
| SCHEMBL7811740 | 0.73 | IDO1 (0.45) | IDO1TDO2NPC1RAB9A | |
| SCHEMBL12713530 | 0.72 | RAB9A (0.58) | MMP2MMP9MMP8MMP13NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |