Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 7/20 | 0.52 |
| ▸ | TDO2 | P48775 | 5/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.37 |
| ▸ | PDE5A | O76074 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811740 | 0.82 | IDO1 (0.45) | IDO1TDO2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7811891 | 0.81 | IDO1 (0.55) | IDO1TDO2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7814769 | 0.81 | IDO1 (0.55) | IDO1TDO2KDM4EALDH1A1MAPT | |
| SCHEMBL7813124 | 0.81 | IDO1 (0.55) | IDO1TDO2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7808342 | 0.81 | IDO1 (0.55) | IDO1TDO2ALDH1A1MAPTNPC1 | |
| SCHEMBL7805846 | 0.78 | IDO1 (0.48) | IDO1TDO2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL7811413 | 0.77 | IDO1 (0.50) | IDO1TDO2NPC1RAB9ABLM | |
| SCHEMBL7816639 | 0.75 | IDO1 (0.57) | IDO1TDO2KDM4EALDH1A1MAPT | |
| SCHEMBL7807731 | 0.74 | IDO1 (0.52) | IDO1TDO2ALDH1A1MAPTNPC1 | |
| SCHEMBL7811377 | 0.74 | IDO1 (0.52) | IDO1TDO2CYP2C19KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | claimed |
| EP-0876356-B1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | INNOTHERA SA LAB (FR) | 2001-10-31 | — | — | EP | disclosed |
| US-6262095-B1 | TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA | LABORATOIRE INNOTHERA (FR) | 2001-07-17 | — | — | US | disclosed |