SCHEMBL7808446

SCHEMBL7808446

O=C1c2ccccc2C(=O)c2oc(-c3cccc(F)c3)nc21

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP1 O94782 5/20 0.72
USP19 O94966 2/20 0.72
UCHL3 P15374 1/20 0.72
WDR48 Q8TAF3 1/20 0.71
OTUB1 Q96FW1 4/20 0.61
USP8 P40818 3/20 0.61
USP36 Q9P275 3/20 0.61
USP2 O75604 2/20 0.61
MAOB P27338 2/20 0.50
NOTUM Q6P988 2/20 0.47
DHODH Q02127 2/20 0.45
HPN P05981 1/20 0.44
TP53 P04637 1/20 0.42
IDO1 P14902 1/20 0.41
TDO2 P48775 1/20 0.41
KDR P35968 1/20 0.41
CYP1A1 P04798 1/20 0.40
CYP1A2 P05177 1/20 0.40
PRKDC P78527 1/20 0.40
CYP1B1 Q16678 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7815859 0.84 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL31276578 0.84 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL29629183 0.84 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL7808226 0.84 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL29629184 0.84 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL7812967 0.83 USP1 (0.71) USP1USP19UCHL3WDR48OTUB1
SCHEMBL19220486 0.78 USP1 (0.82) USP1USP19UCHL3WDR48OTUB1
SCHEMBL7808123 0.78 USP1 (0.68) USP1USP19UCHL3WDR48OTUB1
SCHEMBL29493043 0.76 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1
SCHEMBL19198053 0.76 USP1 (1.00) USP1USP19UCHL3WDR48OTUB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0876356-B1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF INNOTHERA SA LAB (FR) 2001-10-31 EP claimed
EP-0876356-B1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF INNOTHERA SA LAB (FR) 2001-10-31 EP disclosed
US-6262095-B1 TREATMENT OF ILLNESS ASSOCIATED WITH AN ALTERATION IN VENOUS FUNCTION AND/OR INFLAMMATORY EDEMA LABORATOIRE INNOTHERA (FR) 2001-07-17 US disclosed
EP-0876356-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA Société Anonyme (FR) 1998-11-11 EP disclosed
WO-1997021684-A1 USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) 1997-06-19 WO disclosed