Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820260 | 0.92 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL10854878 | 0.89 | ALDH1A1 (0.56) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL7818619 | 0.86 | ALDH1A1 (0.58) | ALDH1A1KMT2AMEN1POLBNISCH | |
| SCHEMBL7818287 | 0.84 | POLB (0.73) | ALDH1A1KMT2AMEN1POLBCYP3A4 | |
| SCHEMBL7810147 | 0.84 | POLB (0.55) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL7820037 | 0.83 | POLB (0.53) | ALDH1A1KMT2AMEN1POLBNPSR1 | |
| SCHEMBL7817587 | 0.83 | POLB (0.54) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL7810528 | 0.83 | POLB (0.54) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL10855360 | 0.81 | ALDH1A1 (0.52) | ALDH1A1KMT2AMEN1POLBTDP1 | |
| SCHEMBL7818136 | 0.81 | ALDH1A1 (0.57) | ALDH1A1KMT2AMEN1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894796-B1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR (FR) | 2001-06-06 | — | — | EP | disclosed |
| US-6057317-A | Heterocyclic compounds | ADIR ET COMPAGNIE (FR) | 2000-05-02 | — | — | US | disclosed |
| EP-0894796-A1 | Imidazolines substituted with a heterocyclic ring as alpha-2 antagonists | ADIR ET COMPAGNIE (FR) | 1999-02-03 | — | — | EP | disclosed |