Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 8/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.45 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | MARK3 | P27448 | 2/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.45 |
| ▸ | MARK2 | Q7KZI7 | 2/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.45 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.45 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.45 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.45 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 4/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7807346 | 0.89 | ROCK2 (0.45) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL23795376 | 0.82 | ROCK2 (0.68) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL30438995 | 0.82 | ROCK2 (0.68) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL23795409 | 0.82 | ROCK2 (0.68) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL2905046 | 0.81 | PRKCD (0.43) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL7814399 | 0.80 | ROCK2 (0.68) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL7807342 | 0.79 | ROCK2 (0.58) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL22024333 | 0.79 | ROCK2 (0.38) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| SCHEMBL7811531 | 0.78 | PRKCD (0.44) | ROCK2ROCK1PRKCDPLK4MARK3 | |
| Trifluoroacetic Acid SCHEMBL23795404 | 0.77 | ROCK2 (0.61) | ROCK2ROCK1PRKCDPLK4MARK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1074545-A1 | ISOQUINOLINESULFONAMIDE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Hidaka, Hiroyoshi (JP) | 2001-02-07 | — | — | EP | disclosed |