Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 20/20 | 0.58 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.55 |
| ▸ | RXRB | P28702 | 8/20 | 0.54 |
| ▸ | RXRG | P48443 | 5/20 | 0.54 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.53 |
| ▸ | CYP26B1 | Q9NR63 | 2/20 | 0.53 |
| ▸ | RARB | P10826 | 3/20 | 0.51 |
| ▸ | RARG | P13631 | 3/20 | 0.51 |
| ▸ | RARA | P10276 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6729166 | 0.85 | RXRA (0.59) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL6730217 | 0.84 | RXRA (0.57) | RXRARXRBRXRGCYP26A1CYP26B1 | |
| SCHEMBL7803730 | 0.83 | RARA (0.46) | RXRANR4A2RXRBRXRGRARB | |
| SCHEMBL7803727 | 0.81 | RXRA (0.46) | RXRANR4A2RXRBRXRGRARB | |
| SCHEMBL7801892 | 0.79 | RXRA (0.58) | RXRANR4A2RXRBRXRGCYP26A1 | |
| SCHEMBL7812219 | 0.79 | RXRA (0.43) | RXRANR4A2RXRBRXRGRARB | |
| SCHEMBL8592924 | 0.79 | RARA (0.40) | RXRANR4A2RXRBRXRGCYP26A1 | |
| SCHEMBL6734814 | 0.79 | RXRA (0.58) | RXRANR4A2RXRBRXRGCYP26A1 | |
| SCHEMBL20876244 | 0.77 | BRD4 (0.52) | RXRACYP26A1CYP26B1RARBRARG | |
| SCHEMBL7799673 | 0.76 | RXRA (0.50) | RXRARXRBRXRGCYP26A1CYP26B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | claimed |
| US-5905088-A | SKIN DISORDERS, RHEUMATIC DISEASES, RESPIRATORY SYSTEM OR CARDIOVASCULAR DISORDERS AND OPTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-05-18 | — | — | US | claimed |
| EP-0816352-B1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CT INTERNAT DE (FR) | 2001-02-21 | — | — | EP | disclosed |
| US-5905088-A | SKIN DISORDERS, RHEUMATIC DISEASES, RESPIRATORY SYSTEM OR CARDIOVASCULAR DISORDERS AND OPTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1999-05-18 | — | — | US | disclosed |
| EP-0816352-A1 | Bi-aryl heterocyclic compounds and their use in human or veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (C.I.R.D. GALDERMA) (FR) | 1998-01-07 | — | — | EP | disclosed |