Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.55 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL896771 | 0.86 | ALK (0.74) | ALKKDRKIT | |
| SCHEMBL24676221 | 0.84 | ALK (0.51) | ALKKDRKITNTRK1LCK | |
| SCHEMBL7808987 | 0.84 | ALK (0.77) | ALKKDRKIT | |
| SCHEMBL7807828 | 0.81 | ALK (0.75) | ALKKDRKIT | |
| SCHEMBL1755742 | 0.80 | ALK (0.62) | ALK | |
| SCHEMBL7810026 | 0.77 | ALK (0.65) | ALK | |
| SCHEMBL7805461 | 0.73 | ALK (0.78) | ALKKDRKIT | |
| SCHEMBL1755799 | 0.71 | ALK (0.73) | ALKKDRKIT | |
| SCHEMBL20004138 | 0.71 | ALK (0.76) | ALKKDRKIT | |
| SCHEMBL897365 | 0.71 | ALK (1.00) | ALKKDRKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441753-A1 | TETRACYCLIC COMPOUND | Chugai Seiyaku Kabushiki Kaisha (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143664-A1 | TETRACYCLIC COMPOUND | 中外製薬株式会社 (JP) | 2010-12-16 | — | — | WO | disclosed |