SCHEMBL7809096

SCHEMBL7809096

O=c1cc(-c2cccc(OC(F)(F)F)c2)c2ccc(Br)cc2o1

nearest known ligand 0.45

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.45
MEN1 O00255 3/20 0.45
KMT2A Q03164 3/20 0.45
CA9 Q16790 4/20 0.45
CA12 O43570 3/20 0.44
KCNA3 P22001 1/20 0.44
MAOB P27338 3/20 0.43
ALDH2 P05091 1/20 0.43
AKR1B1 P15121 1/20 0.43
MAOA P21397 1/20 0.43
HSD17B3 P37058 1/20 0.43
SORD Q00796 1/20 0.43
AR P10275 1/20 0.43
HPGD P15428 4/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
ESR1 P03372 1/20 0.42
MAPT P10636 1/20 0.41
USP2 O75604 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2991933 0.84 KCNA3 (0.61) ALDH1A1MEN1KMT2ACA9CA12
SCHEMBL2979482 0.78 CA9 (0.68) ALDH1A1KMT2ACA9CA12MAOB
SCHEMBL30228183 0.78 CA9 (0.68) ALDH1A1KMT2ACA9CA12MAOB
SCHEMBL757787 0.77 CA12 (0.71) ALDH1A1CA9CA12KCNA3MAOB
SCHEMBL27943255 0.74 MAOB (0.48) ALDH1A1CA9CA12KCNA3MAOB
SCHEMBL7803651 0.73 ALDH1A1 (0.61) ALDH1A1CA9CA12MAOBALDH2
SCHEMBL2985971 0.72 CA12 (0.50) ALDH1A1CA9CA12MAOBALDH2
SCHEMBL26628214 0.72 AR (0.53) ALDH1A1MAOBMAOAARHPGD
SCHEMBL2991679 0.71 CA9 (0.51) ALDH1A1KMT2ACA9CA12KCNA3
SCHEMBL28053824 0.71 GABRP (0.60) CA9CA12MAOBALDH2AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0788497-B1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2001-05-23 EP disclosed
EP-0788490-B1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC (CA) 2000-07-05 EP disclosed
EP-0788490-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1997-08-13 EP disclosed
US-5552437-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY, AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1996-09-03 US disclosed
US-5527827-A ANTIASTHMATIC, ANTIALLERGIC, ANTIINFLAMMATORY AND CYTOPROTECTIVE AGENTS MERCK FROSST CANADA, INC. (CA) 1996-06-18 US disclosed
WO-1996013491-A1 BISARYLCARBINOL CINNAMIC ACIDS AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed
WO-1996013500-A1 BISARYLCARBINOL DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS MERCK FROSST CANADA INC. (CA) 1996-05-09 WO disclosed