Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.84 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7811046 | 0.99 | ALOX5 (0.86) | ALOX5NR3C2OPRM1LMNATSHR | |
| SCHEMBL7815037 | 0.92 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL7802468 | 0.90 | ALOX5 (0.84) | ALOX5NR3C2GRM5CYP1A2CYP3A4 | |
| SCHEMBL7802752 | 0.89 | ALOX5 (0.85) | ALOX5NR3C2GRM5CYP1A2CYP3A4 | |
| SCHEMBL7810991 | 0.82 | ALOX5 (0.57) | ALOX5OPRM1LMNATSHRNPSR1 | |
| SCHEMBL7811849 | 0.82 | ALOX5 (0.81) | ALOX5NR3C2GRM5CYP1A2CYP3A4 | |
| SCHEMBL8408934 | 0.82 | ALOX5 (0.60) | ALOX5NR3C2GRM5CYP1A2CYP3A4 | |
| SCHEMBL7807535 | 0.82 | ALOX5 (0.87) | ALOX5 | |
| SCHEMBL7811973 | 0.82 | ALOX5 (1.00) | ALOX5 | |
| SCHEMBL7811102 | 0.81 | ALOX5 (0.58) | ALOX5OPRM1LMNATSHRNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787127-B1 | 5-LIPOXYGENASE INHIBITORS | PFIZER (US) | 2001-01-03 | — | — | EP | disclosed |
| US-6063928-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS | PFIZER INC (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0787127-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996011911-A1 | 5-LIPOXYGENASE INHIBITORS | PFIZER INC. (US) | 1996-04-25 | — | — | WO | disclosed |