SCHEMBL7809131

SCHEMBL7809131

Cc1nccn1-c1ccc(CCl)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.56
CYP3A4 P08684 3/20 0.55
CYP2D6 P10635 2/20 0.55
CYP1A2 P05177 1/20 0.55
CYP19A1 P11511 1/20 0.55
CYP2C9 P11712 1/20 0.55
CYP2C19 P33261 1/20 0.55
CYP2E1 P05181 1/20 0.50
CYP2A6 P11509 1/20 0.50
ADH5 P11766 2/20 0.47
NR3C2 P08235 5/20 0.45
PSEN1 P49768 1/20 0.45
PSEN2 P49810 1/20 0.45
APH1B Q8WW43 1/20 0.45
NCSTN Q92542 1/20 0.45
APH1A Q96BI3 1/20 0.45
PSENEN Q9NZ42 1/20 0.45
GRM5 P41594 1/20 0.44
PDE3B Q13370 2/20 0.43
PDE3A Q14432 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7809105 0.98 ALDH1A1 (0.54) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL30558759 0.84 ALDH1A1 (0.71) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL300802 0.84 CYP3A4 (0.61) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL112456 0.82 ALDH1A1 (0.56) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL7802849 0.82 ALDH1A1 (0.56) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL1073638 0.79 ALDH1A1 (0.61) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL8268417 0.79 ALDH1A1 (0.65) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL30305324 0.79 ADH5 (0.66) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL10763800 0.77 ALDH1A1 (0.54) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1
SCHEMBL15094392 0.76 ALDH1A1 (0.53) ALDH1A1CYP3A4CYP2D6CYP1A2CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787127-B1 5-LIPOXYGENASE INHIBITORS PFIZER (US) 2001-01-03 EP disclosed
US-6063928-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, CARDIOTONIC AGENTS PFIZER INC (US) 2000-05-16 US disclosed
US-5883106-A 5-lipoxygenase inhibitors PFIZER INC. (US) 1999-03-16 US disclosed
EP-0787127-A1 5-LIPOXYGENASE INHIBITORS PFIZER INC. (US) 1997-08-06 EP disclosed
WO-1996011911-A1 5-LIPOXYGENASE INHIBITORS PFIZER INC. (US) 1996-04-25 WO disclosed
US-5223623-A 2-substituted-1(4)-aryl piperazines and the process for their preparation SCHERING AG (DE) 1993-06-29 US disclosed
EP-0491709-A1 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION SCHERING AKTIENGESELLSCHAFT (DE) 1992-07-01 EP disclosed
US-5051422-A 2-substituted-1(4)-aryl piperazines and the process for their preparation SCHERING AG (DE) 1991-09-24 US disclosed
WO-1991004250-A1 2-SUBSTITUTED-1(4)-ARYL PIPERAZINES AND THE PROCESS FOR THEIR PREPARATION SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) 1991-04-04 WO disclosed